| 李航,周波,王军,龚维,尹晓刚.化学通报,2020,83(5):472-475. |
| 水滑石负载碘催化合成α-氨基腈类衍生物 |
Catalytic Synthesis of α-Amino Nitrile Derivatives by
Hydrotalcite-Supported Iodine |
| 投稿时间：2019-12-02 修订日期：2020-02-25 |
| DOI： |
| 中文关键词: 芳香醛 芳香胺 I2/LDHs |
| 英文关键词:Aromatic aldehyde Aromatic amine I2/LDHs |
| 基金项目:贵州省科技厅科技支撑项目（黔科合支撑［2016］4023）资助 |
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| 中文摘要: |
| 以水滑石（LDHs）负载碘（I2/LDHs）为催化剂，芳香醛、芳香胺和三甲基硅氰（TMSCN）为原料，合成了10种α-氨基腈类衍生物，其结构经1H NMR确认。优化反应条件为：n苯甲醛：n苯胺：nTMSCN=1.0：1.0：1.4，水滑石负载碘10（mol）%作催化剂，甲醇为溶剂，搅拌反应10min，收率最高可达98.3%。 |
| 英文摘要: |
| Using hydrotalcite supported iodine (I2/LDHs) as catalyst, aromatic aldehyde, aromatic amine and trimethylsilycyanide (TMSCN) as raw material, 10 kinds of alpha amino acrylic derivatives were synthesized, and their structures are confirmed by 1H NMR. Under the optimum reaction conditions:nbenzaldehyde:naniline:nTMSCN=1.0:1.0:1.4, hydrotalcite supported iodine (10(mol)%) as catalyst, methanol as solvent, and stirred for 10 minutes. The highest yield of α-aminonitriles can reach 98.3%. |
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