| 唐震华,刘佳敏,付毅红,胡伟男,王贞超,欧阳贵平.化学通报,2021,84(1):47-52. |
| 3-取代吲哚衍生物抗肿瘤活性研究进展 |
| Progress in Antitumor Activity of 3-Substituted Indole Derivatives |
| 投稿时间：2020-06-28 修订日期：2020-09-02 |
| DOI： |
| 中文关键词: 3-取代吲哚 杂环 抗肿瘤活性 |
| 英文关键词:3-substitution indole Heterocycle Antitumor activity |
| 基金项目:国家自然科学基金项目（21867004）、药用植物功效与利用国家重点实验室项目（FAMP201801K）、贵州省科技计划平台项目（黔科合平台人才20185781）和贵州省科技计划项目（黔科合基础20181051）资助 |
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| 中文摘要: |
| 吲哚是一种自然界中广泛存在的化合物，具有抗肿瘤、抗氧化、抗菌等生物活性。在吲哚3-位引入不同的取代基，进行结构的修饰与改造一直是药物研究的热点。本文归纳总结了近年来相关的文献，对吡唑及吡唑啉类、二唑及三唑类、与2-位成环类等不同杂环取代的3-取代吲哚衍生物的抗肿瘤活性进行系统性的综述，以期为高活性抗肿瘤药物的研发提供一定的理论基础。 |
| 英文摘要: |
| Indole is a compound widely found in nature, having a variety of biological activities like antitumor, antioxidant and antibacterial. The introduction of different substituents at the 3-position on the indole ring for structural modification and transformation has always been a drug research hotspot. In this article the related literature in recent years were summarized, and the antitumor activities of 3-substitution indole derivatives with the different heterocycle substituents such as pyrazoles and pyrazolines, diazoles and triazoles, cyclization with 2-position were reviewed in order to provide a theoretical basis for the development of highly active antitumor drugs. |
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