| 刘志平,韦万兴,甘春芳,周敏,刘盛.化学通报,2014,77(10):994-997. |
| 构棘果中苯并吡喃异黄酮的分离、结构修饰及细胞活性 |
| Isolation, Structure Modification and Cytotoxicity of Benzopyranylisoflavones from Cudrania cochinchinensis Fruits |
| 投稿时间：2014-01-13 修订日期：2014-02-06 |
| DOI： |
| 中文关键词: 构棘, 苯并吡喃异黄酮,isoderrone,细胞活性 |
| 英文关键词:Cudrania cochinchinensis benzopyranylisoflavones isoderrone cytotoxicity |
| 基金项目:National Natural Science Foundation of China (81060261); Guangxi Natural Science Foundation (2012GXNSFAA053021) |
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| 中文摘要: |
| 采用硅胶、聚酰胺层析方法从构棘果中分离得到了4个苯并吡喃异黄酮alpinumisoflavone (1), 4’-O-methylalpinmum isoflavone (2), 4’-O-methylderrone (3), isoderrone (4)和两个三萜化合物 (13α, 14β, 17α, 20R)- lanosta-7, 24-diene-3β-ol (5), (13α, 14β, 17α, 20R)-lanosta-7,24-diene-3β-O-actate (6)。以异黄酮isoderrone为原料进行了结构修饰得到5个新异黄酮衍生物，所有异黄酮均采用MTT法对胃癌细胞SGC-7901的毒性进行了活性筛选，化合物4和10对SGC-7901肿瘤细胞有中等程度的抑制作用。 |
| 英文摘要: |
| Four benzopyranylisoflavones including alpinumisoflavone (1), 4’-O-methylalpinmum isoflavone (2), 4’-O-methylderrone (3), isoderrone (4) along with two triterpenoid compounds (13α, 14β, 17α, 20R)-lanosta-7,24- diene- 3β-ol (5), (13α,14β,17α, 20R)-lanosta-7,24-diene-3β-O-actate (6) were isolated from the fruits of Cudrania cochinchinensis. In addition, five new isoflavone derivatives (7~10) were also obtained by the methods of selective methylation, ethylation and selective O-prenylation using natural isoderrone 4 as a starting material. All isoflavones were tested for cytotoxicity against SGC-7901 cell lines by MTT. The result showed compounds 4 and 10 showed moderate cytotoxicity against SGC-7901 cell lines. |
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