| 宋志国,孙啸虎,杨喜宝.化学通报,2014,77(10):990-993. |
| (英)硫酸氢钾高效催化一锅法合成5-未取代的3,4-二氢嘧啶-2(1H)-酮 |
| Potassium Hydrogen Sulfate as an Efficient Catalyst for One-pot Synthesis of 5-Unsubstituted 3,4-Dihydropyrimidin-2(1H)-ones |
| 投稿时间：2014-02-09 修订日期：2014-05-06 |
| DOI： |
| 中文关键词: 3, 4-二氢嘧啶-2(1H)-酮 硫酸氢钾 多组分反应 无溶剂条件 Biginelli-type反应 |
| 英文关键词:3,4-Dihydropyrimidin-2(1H)-ones, Potassium hydrogen sulfate, Multi-component reaction, Solvent-free conditions Biginelli-type reaction |
| 基金项目: |
|
| 摘要点击次数: 2622 |
| 全文下载次数: 0 |
| 中文摘要: |
| 无溶剂条件下，硫酸氢钾可有效催化芳香醛、苯乙酮衍生物和脲三组分“一锅法”Biginelli-type反应合成5-未取代的3,4-二氢嘧啶-2(1H)-酮。确定了较佳反应条件。产品结构经IR、1H NMR、MS、元素分析进行表征。提出了可能的催化作用机理。 |
| 英文摘要: |
| 5-Unsubstituted 3,4-dihydropyrimidin-2(1H)-ones were synthesized efficiently by a one-pot three-component Biginelli-type reaction of aromatic aldehydes, acetophenone derivatives and urea in the presence of KHSO4 under solvent-free conditions. The optimal reaction conditions were determined. The structures of all products were characterized by IR, 1H NMR, MS and elemental analysis. A possible catalytic mechanism was proposed. |
| 查看全文 查看/发表评论 下载PDF阅读器 |
| 关闭 |