| 吴玉芹,李立冬,胡琼,尹飞,胡亚东,张浩,胡益民.化学通报,2014,77(12):1219-1223. |
| 钯催化C-N偶联构筑吲哚衍生物反应研究 |
| Study on Palladium Catalyzed C-N Coupling to Construct Indole Derivatives |
| 投稿时间：2014-03-17 修订日期：2014-04-22 |
| DOI： |
| 中文关键词: 钯催化 合成 C-N偶联 吲哚衍生物 |
| 英文关键词:Palladium-catalyzed, Synthesis, C-N Coupling, Indole derivatives |
| 基金项目:国家自然科学基金项目（面上项目，重点项目，重大项目） |
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| 中文摘要: |
| 以炔基苯胺衍生物为底物，通过钯催化C-N偶联合成一类系列吲哚衍生物。优化实验表明，以2% 醋酸钯，在有机碱的DMF溶液中加热至130℃为最佳实验条件。产物结构经IR、1H NMR、13C NMR、HRMS分析确证，其中化合物2e经X射线单晶衍射分析确证。 |
| 英文摘要: |
| 2-Ethynylaniline derivatives for palladium catalyzed C-N coupling, a series of indole derivatives were synthesized. The following standard reaction conditions have been selected to conduct these studies: substrate (1 equiv) in the presence of 2 mol% of palladium(II) catalyst and 4 mol% of Ph3P with n-Bu3N(2 equiv) as an additive in DMF at 130°C. The products were characterized by IR, 1H NMR, 13C NMR and HRMS diffraction analysis, and compound 2e was confirmed using single-crystal X-ray analysis. |
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