| 陈文彬,曹立,王勇.化学通报,2015,78(1):29-36. |
| (英)硫代氨基甲酸酯和草酰胺酯的合成、表征及抑菌活性 |
| Synthesis, characterization and antifungal activities of thiocarbamates and oxamate |
| 投稿时间：2014-04-09 修订日期：2014-05-12 |
| DOI： |
| 中文关键词: 硫代氨基甲酸酯 草酰胺酯 草酰苯胺酯 三光气 合成 生物活性 |
| 英文关键词:Thiocarbamate, Oxamate, Oxanilate, Triphosgene, Synthesis, Biological, Activities |
| 基金项目:天津市自然科学基金重点项目No. 12JCZDJC22000 |
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| 中文摘要: |
| 为发现具有农业生物活性的先导化合物,本文以三聚光气和草酸二乙酯或者乙基草酰氯为酰化试剂在不同条件下合成了硫代氨基甲酸酯和草酰胺酯或草酰苯胺酯,所有目标化合物的结构都经过质谱、氢谱和碳谱核磁共振的确征。生物活性测试表明硫代氨基甲酸酯1b和1f在浓度为6.25 mg/L时,表现出较好的体外抑菌活性,而草酰胺酯或草酰苯胺酯没有表现出任何农业生物活性。 |
| 英文摘要: |
| In this paper, thiocarbamates and oxamates or oxanilates were synthesized using triphosgene and diethyl oxalate or ethyl oxalyl chloride, respectively, under different conditions for pursuing new lead compounds with agricultural activities. All the title compounds were characterized by mass spectrometry, 1H and 13C NMR spectroscopy, respectively. Biological essay results showed that thiocarbamates 1b and 1f possessed good antifungal activities in vitro at 6.25 mg/L, while oxamates and oxanilates do not possess any activity in agriculture. |
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