| 汪震,郑土才,潘向军,王兵,梅念,郑建霖,聂孝文.化学通报,2014,77(12):1188. |
| Gabriel合成法的研究与应用进展 |
| Advances in Research and Applications of Gabriel Synthesis |
| 投稿时间：2014-05-22 修订日期：2014-07-13 |
| DOI： |
| 中文关键词: Gabriel 邻苯二甲酰亚胺 伯胺 水合肼 二甲基海因 合成 |
| 英文关键词:Gabriel phthalimide primary amine hydrazine hydrate dimethyl- hydantoin synthesis |
| 基金项目:衢州市科技计划项目2013Y001。 |
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| 中文摘要: |
| 本文先简单介绍了Gabriel反应,然后综述了苄位和烯丙位等活泼卤代烃、伯卤代烃、磺酸酯的Gabriel反应,最后综述了邻苯二甲酰亚胺与环氧化合物的缩合、含邻苯二甲酰亚胺基的合成子、邻苯二甲酰亚胺与醇在Mitsunobu条件下的直接Gabriel反应等,最后对Gabriel反应的应用进行了总结和展望。指出应加强对Gabriel反应的系统研究,特别是脱邻苯二甲酰基的方法和基于Gabriel反应原理的替代方法的研究。 |
| 英文摘要: |
| This review first introduced Gabriel reaction, then discussed Gabriel reactions of active halides such as benzyl- and allyl- halides, primary halides, and sulfonates , and finally on the Gabriel reactions of phthalimide with epoxy compounds, phthalimide-containing synthons, and direct reaction of phthalimide with alcohol under Mitsunobu conditions, and finally summarized and overviewed the development of Gabriel reaction. Further and systematic studies are clearly needed for Gabriel reaction, and particularly methods for the removal of the phthalimide functionality and replacement methods based on Gabriel reaction principles. |
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