| 刘睿智,张新生,杨海清,申东升.化学通报,2015,78(7):627-632. |
| 羧基亚胺配体的合成及其促进Suzuki偶联反应的研究 |
| Carboxylic Imine Ligands: the Synthesis and Their Applications for Suzuki Cross-Coupling Reaction |
| 投稿时间：2014-11-02 修订日期：2014-12-11 |
| DOI： |
| 中文关键词: Suzuki交叉偶联反应 羧基亚胺 过渡金属钯催化 |
| 英文关键词:Suzuki cross-coupling reaction carboxylc imine ligands transition metal palladium catalyst |
| 基金项目:国家自然科学基金项目 |
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| 中文摘要: |
| 合成了4种羧基亚胺配体并将其用于促进Suzuki偶联反应。通过考察配体结构、溶剂极性、碱强度和温度等因素对反应产率的影响,确定了羧基亚胺配体参与的钯催化Suzuki偶联反应的最佳条件：催化剂的量为0.001 mol %的PdCl2和0.002 mol %的配体,以碳酸钾作碱,乙醇：水=2 mL:2mL作溶剂,反应温度为60oC,在空气条件下反应。结果表明,羧基亚胺配体能够有效促进Suzuki偶联反应；在合成的配体L1-L4中,具有适当的位阻和给电子基团的L2具有最佳的催化活性,能够高效合成一系列联芳类化合物。 |
| 英文摘要: |
| Four kinds of carboxylic imine ligands were synthesized and applicated for Suzuki cross-coupling reaction. The effects of ligand structure, solvent, base and temperature on Suzuki cross-coupling reaction were investigated. It was found that at the aerobic reaction conditions with a loading of 0.001 mol% PdCl2 and 0.002 mol% L2, in the presence of K2CO3 and EtOH:H2O=2 mL:2 mL, the carboxylic imine palladium catalyst showed highly efficiency, and a number of biaryls were synthesized. |
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