| 林桂汕,黄翊,段文贵,岑 波,雷福厚.化学通报,2015,78(8):722-727. |
| 樟脑基苯基硫脲类化合物的合成及生物活性研究 |
| Synthesis and biological activity of camphor-based phenyl thiourea compounds |
| 投稿时间：2014-12-19 修订日期：2015-03-08 |
| DOI： |
| 中文关键词: 樟脑 樟脑基苯基硫脲 合成 杀菌活性 除草活性 |
| 英文关键词:Camphor, Camphor-based phenyl thiourea, Synthesis, Fungicidal activity, Herbicidal activity |
| 基金项目:国家自然科学基金项目;广西林产化学与工程重点实验室开放基金 |
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| 中文摘要: |
| 以D-(+)-樟脑为原料,经肟化、还原得到樟脑胺,再与取代苯基异硫氰酸酯反应,合成得到10个未见文献报道的樟脑基苯基硫脲化合物(5a ~ 5j),其结构通过FT IR、1H NMR、13C NMR和ESI - MS进行分析和表征。初步生物活性测试表明,目标化合物在浓度50 mg/L下对5种供试植物病原菌显示不同程度的抑菌活性,其中化合物5f (R = m - OCH3)和5d (R = p - CH3)对苹果轮纹病菌(Physalospora piricola)和番茄早疫病菌(Cercospora arachidicola)的抑制率分别达83.9%和82.2%；在浓度100 mg/L下,化合物5i (R=p - Br)对油菜(Brassica campestris)胚根生长的抑制率为60.2%。 |
| 英文摘要: |
| Camphoramine was synthesized by oximation and reduction reaction from D-( )-camphor. Then, ten novel camphor-based phenyl thiourea compounds (5a ~ 5j) were prepared by the reaction of camphoramine with various substituted phenyl isothiocyanates. The target compounds were analyzed and characterized by FT IR, 1H NMR, 13C NMR and ESI - MS. The preliminary bioassay showed that, at the concentration of 50 mg/L, the target compounds exhibited different fungicidal activities against the five tested fungi, in which compounds 5f (R=m - OCH3) and 5d (R=p - CH3) had inhibition rates of 83.9% and 82.2% against Physalospora piricola and Cercospora arachidicola, respectively. Besides, at the concentration of 100 mg/L, compound 5i (R=p - Br) displayed growth inhibition rate of 60.2% against rape root (Brassica campestris). |
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