| 毛泽伟,王兆良,饶高雄.化学通报,2015,78(8):761-763. |
| 4R-岩白菜素的合成 |
| Studies on synthesis of 4R-Bergenin |
| 投稿时间：2015-01-02 修订日期：2015-03-08 |
| DOI： |
| 中文关键词: 岩白菜素 构型转化 合成 |
| 英文关键词:Bergenin, Configuration transformation, Synthesis |
| 基金项目:云南省应用基础研究计划项目（2013FZ088） |
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| 中文摘要: |
| 岩白菜素为碳苷类化合物,具有广泛的生理活性。本文通过一系列反应,将岩白菜素分子中4-OH的构型由S转化为R,合成得到其非对映异构体4R-岩白菜素,为岩白菜素的衍生化研究提供了新的思路。 |
| 英文摘要: |
| Bergenin is a kind of carbon glycosides, which has a wide range of biological activities. In this work, 4S-OH of Bergenin was conversed to 4R-OH through a series of reactions, such as selective protection, oxidation and stereoselective reduction. So 4R-Bergenin was synthesized from bergenin, which provided a novel research idea for it’s derivatization. |
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