| 赵晓珑,刘晓媛,杨瑞波,申倩倩,王科志.化学通报,2015,78(10):873-881. |
| 钌配合物与G-四链体DNA的相互作用研究进展 |
| Progress in Studies of Interaction between Ruthenium Complexes and G-quadruplex DNA |
| 投稿时间：2015-01-18 修订日期：2015-03-06 |
| DOI： |
| 中文关键词: 钌 G-四链体DNA 端粒酶 抗肿瘤 |
| 英文关键词:Ruthenium G-quadruplex DNA Telomerase Antitumor |
| 基金项目:国家自然科学基金项目 |
|
| 摘要点击次数: 2800 |
| 全文下载次数: 0 |
| 中文摘要: |
| 人体端粒由富含鸟嘌呤(G)的DNA重复序列组成,该序列在一定条件下可以形成G-四链体DNA结构。小分子化合物诱导该结构的形成并使之稳定,可以抑制端粒酶活性而达到抗肿瘤的目的。因此,G-四链体DNA稳定剂的设计和筛选是近年来生物无机化学的重要前沿研究领域之一。在金属配合物中,钌配合物由于具有丰富的光化学、光物理特性以及生物活性,其作为G-四链体DNA稳定剂引起人们的高度关注。本文以近年一些代表性的研究工作为例,对钌配合物与G-四链体DNA相互作用方面的研究进展进行了综述。 |
| 英文摘要: |
| Human telomere consists of a series of DNA sequences rich in Guanine, and may form G-qudruplex structure under certain conditions. The formation and stabilization of the specific structure by small molecules could inhibit the telomerase and thus contribute to the antitumor action. So the designing and screening of stabilizers of G-quadruplex DNA has been one of the focuses of inorganic biochemistry in recent years. Ruthenium complexes, which possess superior photochemical, photophysical and bioactivity in comparison to other metal complexes, have also received intense interest as G-quadruplex stabilizers. In this review, the recent representive advances on the reaction between ruthenium complexes and G-quadruplex DNA are highlighted. |
| 查看全文 查看/发表评论 下载PDF阅读器 |
| 关闭 |
|
|
|