| 王敏,宋吉磊,潘鹤,刘洋.化学通报,2015,78(10):949-852. |
| 无溶剂条件下对甲基苯磺酸铝高效催化合成4,6-二芳基-3,4-二氢嘧啶-2(1H)-酮 |
| Efficient Synthesis of 4,6-Diaryl-3,4-dihydropyrimidin-2(1H)-ones Catalyzed by Aluminum p-Toluenesulfonate under Solvent-free Conditions |
| 投稿时间：2015-01-24 修订日期：2015-03-31 |
| DOI： |
| 中文关键词: 4,6-二芳基-3,4-二氢嘧啶-2(1H)-酮 对甲基苯磺酸铝 无溶剂 一锅法 |
| 英文关键词:4,6-Diaryl-3,4-dihydropyrimidin-2(1H)-ones, Aluminum p-toluenesulfonate, Solvent-free, One-pot synthesis |
| 基金项目:国家自然科学基金项目 |
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| 中文摘要: |
| 以芳香醛、芳香酮和尿素为原料,对甲基苯磺酸铝为催化剂,在90oC、无溶剂条件下“一锅法”反应,高效合成了一系列4,6-二芳基-3,4-二氢嘧啶-2(1H)-酮。产品结构通过IR,1H NMR,13C NMR和元素分析进行了表征。该方法具有操作简单、反应时间短、产率高、反应条件温和、不使用任何有机溶剂、催化剂廉价易得且可重复使用等优点,为标题化合物的合成提供了一种简便高效的绿色新途径。 |
| 英文摘要: |
| The 4,6-diaryl-3,4-dihydropyrimidin-2(1H)-ones were synthesized by an one-pot three-component condensation of aromatic aldehydes, aromatic ketones and urea in the presence of aluminum p-toluenesulfonate under solvent-free conditions at 90 oC. All products were characterized by IR, 1H NMR, 13C NMR and elemental analysis. The advantages of this method include the simple procedure, short reaction time, high yields, mild conditions, the avoidance of the use of organic solvents, inexpensive and reusable catalysts. It provides a new simple and green synthetic method for the title compounds. |
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