| 梅苏宁,杨建明,王为强,张前,余秦伟,赵锋伟,李亚妮,吕剑.化学通报,2015,78(10):882-888. |
| 铜催化卤代芳烃氨解反应的研究进展 |
| Progress in Copper-Catalyzed Ammonolysis of Aryl Halide |
| 投稿时间：2015-02-02 修订日期：2015-03-15 |
| DOI： |
| 中文关键词: 铜 催化 卤代芳烃 氨解 芳胺 |
| 英文关键词:Copper Catalysis Aryl Halides Ammonolysis Aromatic Amine |
| 基金项目: |
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| 摘要点击次数: 2971 |
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| 中文摘要: |
| 铜催化卤代芳烃进行氨解反应是构建C-N键的重要方法。铜作为催化剂不仅便宜、丰富、相对低毒，而且可以通过几个氧化态进行循环催化。配体的发展则扩展了底物的适用范围，提高了官能团的兼容性和反应的选择性，使得该反应成为一种通用的制备芳胺方法。本文以铜盐催化剂为线索，对该反应机理进行了简介，对近年来铜催化卤代芳烃的氨解反应的研究进展进行了综述和展望。并指出高活性和高选择性的催化体系依然有限，铜催化剂使用量仍然较高，氨和氯代芳烃的使用还不够广泛，而且缺乏关于该类反应详细机理的文献报道。此外，发展一个新的、高效的和通用的氨解方法仍然显得极为迫切。 |
| 英文摘要: |
| It is an important method to form C-N by copper-catalyzed ammonolysis of aryl halide. Copper is not only one of the cheapest, most abundant and relatively, a less toxic catalyzer, but also may be involved in catalytic cycles through several oxidation states. The deveiopment of ligands expands the scope of substrates, improves the compatibility of functional groups and reaction seiectivity. These works make this reaction becoming a versatile method for preparing and producing aromatic amine compounds. The reaction mechanism is surveyed, and the research progress in copper-catalyzed ammonolysis of aryl halide is reviewed and prospected by using copper salts catalysts as clue. Highly active and selective catalysts remain limited, the amounts of copper catalyst are large all the same, and ammonia and aryl chlorides are still not widely used. Further more, the detailed reaction mechanism is scarce. In addition, developing a new, efficient and versatile ammonolysis method is still exigent. |
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