| 杨万丽,苏兆轩,陈林,王清文.化学通报,2016,79(1):56-61. |
| 带有乙烯基苄基的长链季铵盐的合成及安全性研究 |
| StudySonStheSsynthesisSandSsafetySofSlongSchainSquaternarySammoniumSsaltSwithSvinylSbenzylYANG Wan-Li1SU Zhao-Xuan1 CHEN Lin1 WANG Qing-Wen2 |
| 投稿时间：2015-05-07 修订日期：2015-07-14 |
| DOI： |
| 中文关键词: 季铵盐 合成 抗菌机理 安全性 |
| 英文关键词:quatemary ammonium salt synthetic Antibacterial mechanism Safety |
| 基金项目:(No2012-01)资助；黑龙江省自然科学(N0.B201420)资助；黑龙江省教育厅面上项目(12541895)资助；齐齐哈尔科技局工业攻关指导项目(G12D2013013)；齐齐哈尔大学青年教师科研启动支持计划项目资助( 项目编号2014k-Z09)；2015年黑龙江省大学生创新创业训练计划资助项目（201510221022） |
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| 中文摘要: |
| 以对乙烯基卞基氯(C9H9Cl)为原料与二甲基十六烷基叔胺(16DMA)合成N,N-二甲基十四烷基对乙烯基苄基氯化铵(C9H9Cl-16DMA)新型季铵盐抗菌单体，并用FT-IR、H-NMR、EA、TG等手段表征其结构；季铵盐单体采用抑菌圈法对大肠杆菌、金黄色葡萄球菌和枯草芽孢杆菌抑菌活性进行测；通过家兔的生理特征测试、急性皮肤刺激性实验和小鼠经口毒性实验表征了该季铵盐单体对人体的安全性，毒理实验结果显示，家兔生理特征无异样变化；家兔的皮肤没有任何变化，根据寇氏法公式求出单体对小鼠的7d的LD50及其95%可信限范围为3000.68 (2560.57～3440.79)mg/kg。 |
| 英文摘要: |
| In this paper, 1-(Chloromethyl)-4-vinylbenzene (C9H9Cl) as raw material, a new type quaternary ammonium salt antibacterial monomer, namely C9H9Cl-16DMA, was synthesized through nucleophilic substitution reaction with N, N- dimethylcetylamine (16DMA). The structure of sample was observed by using FT-IR, H-NMR, EA, TG characterization means. The antibacterial activities of composite were tested for staphylococcus aureus, bacillus subtilis and escherichia coli by the inhibition zone method.From the point of future application and safety, we evaluate the toxicity of C9H9Cl-16DMA. The results of toxicity experiments show that there are no abnormal change in the physiological characteristics and the skin of rabbit. We calculate by Karber’s method that the scope of LD50 is 3000.68(2560.57～3440.79)mg/kg. |
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