| 刘玮炜,程峰昌,殷龙,李曲祥.化学通报,2016,79(1):77-82,76. |
| 含D-氨基葡萄糖分子的酰基硫脲衍生物合成 |
| Synthesis of D-Glucosamine Acylthiourea Derivatives |
| 投稿时间：2015-05-18 修订日期：2015-06-18 |
| DOI： |
| 中文关键词: D-氨基葡萄糖 酰基硫脲 合成 |
| 英文关键词:D-glucosamine Acylthiourea Synthesis |
| 基金项目: |
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| 中文摘要: |
| 以D-氨基葡萄糖盐酸盐原料,经酰化保护羟基后得1,3,4,6-四-O-乙酰基-2-脱氧-β-D-氨基葡萄糖,再与芳酰基异硫氰酸酯反应合成12种新型的糖基酰基硫脲衍生物。优化实验表明,反应物(5)：反应物(4)反应摩尔配比 = 1:1.2,在二氯甲烷溶液中加热至40℃,反应6 h为最佳反应条件。产物结构经 IR、1 H NMR、13 C NMR分析确证。 |
| 英文摘要: |
| Twelve kinds of D-glucosamine acylthiourea derivatives were sythesized from acyl isothiocyanate and 1,3,4,6-tetra-O-acetyl-2-deoxy-β-D-glucosamine hydrochloride prepared from D-glucosamine hydrochloride by protection of amino group followed by acetylation of hydroxyl group, and deprotection of the amine group, the optimal conditions for the coupling reaction were the molar ratio of acyl isothiocyanate and 1,3,4,6-tetra-O-acetyl-2-deoxy-β-D-glucosamine 1:1.2 in dichloromethane at 40℃ for 6 hours, The products were characterized by IR, 1H NMR and 13C NMR. |
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