| 杨鹏辉,孙伟.化学通报,2015,78(12):1170-1172. |
| 新型苯并咪唑取代的丙烯腈衍生物的催化合成 |
| Catalyzed Synthesis of New Benzimidazole Acrylonitrile Derivatives |
| 投稿时间：2015-05-25 修订日期：2015-07-03 |
| DOI： |
| 中文关键词: 2-腈甲基苯并咪唑 Knoevenagel反应 合成 |
| 英文关键词:2-cyanomethylbenzimidazole, Knoevenagel reaction, synthesis |
| 基金项目:国家自然科学基金(21376189)；西安市科技计划项目(CXY1435(5)) |
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| 中文摘要: |
| 从邻苯二胺出发,合成了2-腈甲基苯并咪唑,对2-腈甲基苯并咪唑与醛的Knoevenagel缩合反应催化剂进行了优选,研究表明,吗啡啉/乙酸是催化2-腈甲基苯并咪唑与芳香醛Knoevenagel缩合反应的良好催化剂；在吗啡啉/乙酸催化下,合成了新型的双苯并咪唑丙烯腈衍生物和3-吲哚-2-苯并咪唑丙烯腈衍生物；将2-腈甲基苯并咪唑经过碱性水解,酯化,得到苯并咪唑乙酸乙酯,后者经过次序Knoevenagel缩合/分子内酯交换高产率地得到了新型的苯并咪唑取代的香豆素衍生物。 |
| 英文摘要: |
| 2-Cyanomethylbenzimidazole was synthesized from o-phenylene diamine and the Knoevenagel reaction catalysts of 2-cyanomethylbenzimidazole with aromatic aldehyde were optimized. It was found that morpholine/acetic acid was an effective catalyst for the Knoevenagel reaction of 2-cyanomethylbenzimidazole with aromatic aldehyde. New bis-benzimidazole acrylonitrile and indolyl benzimidazole acrylonitrile derivatives were prepared. 2-benzimidazoleacetate prepared by hydrolysis and esterifacation underwent sequential Knoevenagel and intramolecular transesterification to give benzimidazolyl coumarin derivatives in high yield. |
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