| 郑程隆,康从民.化学通报,2016,79(5):463-465. |
| 3-氨基-2-吲哚酮的新合成方法 |
| Novel Method for Synthesis of 3-Aminoindolin-2-one |
| 投稿时间：2015-09-08 修订日期：2015-11-15 |
| DOI： |
| 中文关键词: 苯胺 盐酸羟胺 靛红 钯碳加氢 3-氨基-2-吲哚酮 |
| 英文关键词:Aniline, Hydroxylamine hydrochloride, Isatin, Palladium hydrogenation,3-Aminoindolin-2-one |
| 基金项目:国家自然科学基金项目（21072111, 21272131） |
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| 中文摘要: |
| 以苯胺为原料，通过传统方法合成靛红。靛红与盐酸羟胺反应生成3-羟基亚氨基-2-吲哚酮，再通过钯碳加氢还原生成3-氨基-2-吲哚酮。合成中，采用钯碳加氢的还原方式，产物收率提高（收率82.76%，较文献提高了11.8%），后处理更简单，而且该方法可操作性高，成本低，产生三废少，是一条适合大规模生产3-氨基-2-吲哚酮的新合成工艺路线。 |
| 英文摘要: |
| Isatinwas synthesized by using aniline as raw material through traditional methods. 3-(Hydroxyimino)indolin-2-one was synthesized by the reaction of isatin and hydroxylamine hydrochloride, after that 3-aminoindolin-2-one was getted via palladium hydrogenation reduction.In synthesis,palladium hydrogenation reduction was used, which made the product yield higher (82.8% yield, compared with the literature improve 11.8%), and made postprocessing more simple. This method has high operability., low cost, environmental protectionand is suitable for mass production without purification of the intermediates. |
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