| 尹晓刚,吴小云,王野,陈治明,陈卓.化学通报,2016,79(9):834-838. |
| I2负载蒙脱土超声法催化Biginelli反应 |
| Biginelli reaction catalysized by I2 loaded montmorillonite under ultrasonic conditions |
| 投稿时间：2016-01-07 修订日期：2016-03-13 |
| DOI： |
| 中文关键词: 蒙脱土 I2 超声 Biginelli反应 |
| 英文关键词:montmorillonite I2 Ultrasonic assisted Biginelli reaction |
| 基金项目:国家自然(NO.21362006)；贵州省科学技术,黔科合J字[2014]2129号 |
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| 中文摘要: |
| 以芳香醛、乙酰乙酸乙酯及脲为原料,I2负载蒙脱土为催化剂,对超声条件下Biginelli反应进行研究。单因素法考察溶剂及催化剂对产率的影响,正交试验优化温度、超声时间及原料摩尔比。最优条件为：反应温度80℃,超声时间5min,芳香醛、乙酰乙酸乙酯和脲的摩尔比为1：1：1,催化剂用量为10%(醛摩尔比)的最优条件下,产率最高可达86.9%。合成的7种3,4-二氢嘧啶-2(1H)-酮衍生物通过红外、核磁、熔点进行表征。 |
| 英文摘要: |
| An ultrasound-assisted biginelli reaction catalysized by I2 loaded montmorillonite was developed using ethylacetoacetate,aromaticaldehyde and urea as starting material. Influences of solvents,catalysts, quivalency of starting materials on yields were investigated using single factor methods and the temperature, ultrasonic time were investigated using orthogonal tests. Under the optimized conditoins, yields of 3,4-Dihydropyrimidin-2(1H)ones derivatives up to 86.9%. The products were characterized by 1H NMR,IR and M.P. |
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