| 刘玮炜,刘秀坚,殷龙,程峰昌.化学通报,2016,79(10):929-935,941. |
| 1,3,4-噻二唑衍生物合成及其生物活性研究进展 |
| Progress in Chemical Synthesis and Biological Activities of 1,3,4-Thiadiazole Derivatives |
| 投稿时间：2016-01-11 修订日期：2016-04-08 |
| DOI： |
| 中文关键词: 1,3,4-噻二唑 衍生物 合成方法 生物活性 |
| 英文关键词:1,3,4-Thiadiazole Derivatives Synthesis methods Biological activity |
| 基金项目:江苏省海洋生物技术重点实验室研究基金(HS2014007),连云港市科技攻关项目(CG1415)资助，海洋公益性行业科研专项经费资助(201505023) |
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| 中文摘要: |
| 1,3,4-噻二唑是含有N, S杂原子的五元杂环化合物,具有多种生物活性。目前,1,3,4-噻二唑及其衍生物广泛地运用于生物、医药等领域,尤其在抗菌、抗肿瘤、抗癌等方面的研究已取得重大突破。由于1,3,4-噻二唑结构的特殊性以及优越的生物活性,对其进行研究有重要意义。为此,本文主要概述了近年来1,3,4-噻二唑衍生物的几种合成方法以及其在抗菌、抗肿瘤、抗癌方面的研究进展。 |
| 英文摘要: |
| 1,3,4-thiadiazole is five-membered heterocyclic compound which contains heteroatoms of N and S, having a variety of biological activities. The derivatives of 1,3,4-thiadiazoles have been applied to the fields of biology, medicine and others, and have made breakthrough in such aspects as antibacterial, antitumor, anticancer research. It is of great significance to research on its derivatives due to special structure and superior biological activities. Therefore, the review has a closer look at the synthesis methods and the research of antibacterial, antitumor, anticancer of the derivatives of 1,3,4-thiadiazoles. |
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