| 高蕾,王兰芝.化学通报,2017,80(1):64-68. |
| 2-取代芳基-4-丙酸乙酯基-1,5-苯并二氮卓衍生物的高效合成 |
| An Efficicent Catalytic Synthesis of Derivatives of 2- aryl-4-yl propanoate -1,5- Benzodiazepin |
| 投稿时间：2016-04-14 修订日期：2016-06-22 |
| DOI： |
| 中文关键词: 克诺维纳盖尔缩合 环合 2-取代芳基-4-丙酸乙酯基-1,5-苯并二氮杂卓 |
| 英文关键词:Knoenenagel reaction cyclization 2-aryl-4-yl propanoate-1,5- benzodiazepin |
| 基金项目:国家自然科学基金项目（21276064），河北省自然科学基金（B2016205165） |
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| 中文摘要: |
| 以取代的芳香醛和乙酰丙酸乙酯为原料,通过克诺维纳盖尔(Knoevenagel)缩合、亲核加成、环合、脱水等过程,快速高效地合成了8种未见文献报道的2-芳基-4-丙酸乙酯基-1,5-苯并二氮杂卓化合物.通过1H NMR、13C NMR、IR、MS和单晶衍射确定了其目标产物结构,对合成目标化合物的反应条件进行了较详细的研究,并提出了可能的反应机理。 |
| 英文摘要: |
| Eight novel compounds of 2-aryl-4-yl propanoate-1,5-benzodiazepin were efficiently synthesized by the Knoevenagel reaction, nucleophilic addition reaction, dehydration cyclization reaction, using substituted aromatic aldehyde and ethyl levulinate as starting material .The structures of these new compounds were determined by 1H NMR,13C NMR, IR, MS and Diffraction. The exhaustive researches on the synthetic reaction of the class of compounds were carried out and the reaction mechanism has been unequivocally established in this paper. |
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