| 张晓鹏,李政伟,王岩,牛雪利,张贵生.化学通报,2016,79(12):1192-1195. |
| 硒催化羰基化合成敌草隆 |
| Selenium-catalyzed Carbonylation to Diuron |
| 投稿时间：2016-04-16 修订日期：2016-06-17 |
| DOI： |
| 中文关键词: 硒催化剂 羰基化 敌草隆 |
| 英文关键词:Selenium catalyst, Carbonylation, Diuron |
| 基金项目:河南省高校科技创新团队支持计划（15IRTSTHN003）、河南省高等学校青年骨干教师资助计划项目（2013GGJS-059） |
|
| 摘要点击次数: 2694 |
| 全文下载次数: 0 |
| 中文摘要: |
| 本文报道了一种简易、绿色的合成敌草隆的新方法。以3, 4-二氯硝基苯和二甲胺盐酸盐为起始原料，以CO替代剧毒光气作羰基化试剂，经硒催化的“一锅煮”的氧化还原羰基化反应来直接合成出目标产物。通过考察反应时间、温度、溶剂和碱的种类、CO压力以及物料比等因素，获得了优化的反应条件。在优化条件下，能以70%的产率得到目标产物，从而为除草剂敌草隆的合成开辟出一条路线简短、操作简单、成本低、原子经济性高、环境友好的新途径。并在文末提出了可能的反应机理。 |
| 英文摘要: |
| A facile, green approach to diuron is reported. Using cheap, well-available nonmetal selenium as the catalyst, CO instead of virulent phosgene as the carbonylation reagent, the target product can be obtained directly by one-pot selenium-catalyzed redox carbonylation of 3, 4-dichloronitrobenzene with dimethylamine hydrochloride. The optimal reaction conditions were obtained through experimental researches on reaction time, temperature, kinds of solvents and bases, CO pressure and mole ratio of dimethylamine hydrochloride to 3, 4-dichloronitrobenzene etc. Under the optimal reaction conditions, the target product can be obtained in 70% yield. Thus, a brief, simple, low-cost, high atom economic, and environmentally friendly approach to diuron is developed. A plausible route to diuron was presented at the end of this paper. |
| 查看全文 查看/发表评论 下载PDF阅读器 |
| 关闭 |
|
|
|