| 吴小云,尹晓刚,龚维,陈治明,陈卓.化学通报,2016,79(12):1156-1160. |
| 醋酸锌催化串联反应合成2-氨基-3-氰基-4H-吡喃类衍生物 |
| Synthesis of 2-amino-3-cyano -4H- pyran derivatives catalyzed by Zinc acetate |
| 投稿时间：2016-05-22 修订日期：2016-07-04 |
| DOI： |
| 中文关键词: 醋酸锌 串联反应 2-氨基-3-氰基-4H-吡喃类衍生物 |
| 英文关键词:Zinc acetate Tandem reaction 2-Amino-3-cyano-4H-pyran derivatives |
| 基金项目:国家自然(NO.21362006)；贵州省科学技术项目(黔科合J字[2014]2129)；贵州省科技创新人才团队建设项目(黔科合人才团队[2014]4006号) |
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| 中文摘要: |
| 以氰基查尔酮类化合物及丙二腈为原料,醋酸锌为催化剂,经串联反应合成2-氨基-4H-吡喃类衍生物。考察催化剂、溶剂、反应时间及温度、原料摩尔比对产率的影响。最优条件为：氰基查尔酮类化合物与丙二腈物质的量比为1.0:1.0,醋酸锌(10mol%)作催化剂,二氯甲烷作溶剂,反应温度为30℃,产率最高为99.5%。 |
| 英文摘要: |
| 2-Amino -4H- pyran derivatives were synthesized catalyzed by zinc acetate using cyano chalcones and malononitrile as raw material. Influences of catalysts, solvents, reaction time and temperature, mole ratio of raw material on yields were studied. Optimal conditions are: molar ratio of cyano chalcones and malononitrile is 1.0: 1.0, zinc acetate (10mol%) as catalyst, methylene chloride as solvent, the reaction temperature is 30 ℃, the yield up to 99.5%. |
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