| 王桂霞,张洲洋,刘鹏,廖培海,孔翔飞.化学通报,2017,80(4):322-328. |
| 具有生物活性的4-色满酮衍生物的合成进展 |
| Progress in the Synthesis of 4-Chromanone Derivatives with Bioactivity |
| 投稿时间：2016-07-20 修订日期：2016-10-07 |
| DOI： |
| 中文关键词: 4-色满酮衍生物 生物活性 不对称合成 环化 |
| 英文关键词:4-Chromanone derivatives Bioactivty Asymmetric synthesis Cyclization |
| 基金项目:国家自然科学基金项目(11364013) |
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| 中文摘要: |
| 4-色满酮衍生物在自然界中广泛存在,大多数都具有生物活性。具有生物活性的4-色满酮衍生物又大多具有手性,尤其C2位置。有关它们的不对称合成引起了有机合成工作者的广泛关注。C2(手性)-4-色满酮衍生物合成的关键是C2手性中心的控制合成。本文根据4-色满酮衍生物构建方式的不同进行分类,概述了近十几年来合成C2(消旋或手性)4-色满酮衍生物的最新方法, 侧重讨论了合成立体结构专一的C2(手性)-4-色满酮的反应特点。 |
| 英文摘要: |
| 4-Chromanone derivatives are widespread in nature, most of which have bioactivities. 4-chromanone derivatives with bioactivities are chiral compounds, especially C2. Their asymmetric syntheses have been attracting great attention. The key step of synthesizing of 4-chromanone derivatives is to control the synthesis of C2 chiral center. In this paper, based on the different ways of synthesizing 4-chromanone derivatives, various methods of controlling C2 (racemic or chiral)-4-chromanone derivatives in recent years were summarized, especially focus on discussing the reaction characteristics of synthesizing C2 (chiral) -4-chromanone derivatives. |
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