| 王方元,姚克平,彭安顺,王程宇.化学通报,2017,80(6):524-532,543. |
| 基于构建碳-磷键反应的研究进展 |
| Progress on the construction of C-P bonds |
| 投稿时间：2016-08-02 修订日期：2016-09-27 |
| DOI： |
| 中文关键词: 有机磷化学 碳-磷键 偶联反应 磷自由基 |
| 英文关键词:Organophosphorus, C-P bonds, Coupling reactions, Phosphorus radicals |
| 基金项目: |
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| 摘要点击次数: 4527 |
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| 中文摘要: |
| 含磷有机化合物在医药化学、材料化学、有机合成化学等领域的出色应用，使得如何高效构建碳-磷键成为有机合成化学领域的研究热点。本文就近几十年来发展的碳-磷键的构建方法展开综述：包括传统的合成方法、传统的偶联反应、碳-氢键与磷-氢键直接氧化去氢偶联、磷自由基对不饱和键的多米诺反应及不对称碳-磷键偶联反应等，概述每类方法的优缺点，指出目前面临的挑战及发展方向。 |
| 英文摘要: |
| Organophosphorus compounds are widely used in pharmacy chemistry, material science, and organic synthesis. So how to construct C-P bonds become a focus in the field of organic synthesis chemistry. In this paper, progresses on the construction of C-P bonds in recent years were reviewed, including: Traditional synthetic methods、Conventional C-P coupling reactions、Direct oxidative dehydrogenation coupling、The domino reactions between phosphorus radicals with unsaturated bonds、Asymmetric C-P cross-coupling. Their merits、challenges、development directions were also discussed. |
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