裴学海,黄克俊,尹晓刚,陈治明.化学通报,2017,80(5):477-481.
吡咯烷类有机小分子催化合成 1,4-二氢吡啶衍生物
Synthesis of 1,4-Dihydropyridine Derivatives Catalyzed by Pyrrolidines Organic Small Molecules
投稿时间:2016-10-31  修订日期:2016-12-26
DOI:
中文关键词:  吡咯烷衍生物  1,4-二氢吡啶衍生物  Hantzsch反应  循环催化
英文关键词:Pyrrolidine derivatives  1,4-Dihydropyridine derivatives  Hantzsch reaction  Catalytic cycle
基金项目:国家自然科学基金(21362006)资助项目;贵州省自然科学基金(黔科合J字[2009]2021)
作者单位E-mail
裴学海 贵州师范大学 化学与材料科学学院 贵州省功能材料化学重点实验室 546565457@qq.com 
黄克俊 贵州师范大学 化学与材料科学学院 贵州省功能材料化学重点实验室  
尹晓刚 贵州师范大学 化学与材料科学学院 贵州省功能材料化学重点实验室  
陈治明* 贵州师范大学 化学与材料科学学院 贵州省功能材料化学重点实验室 czm000219@163.com 
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中文摘要:
      对以芳香醛、乙酰丙酮及碳酸氢铵为原料,苯甲酰胺吡咯烷为催化剂,合成 1,4-二氢吡啶的反应进行了研究。考察了催化剂、溶剂、温度、时间和氮源对产率的影响。结果表明,反应温度 70℃,芳香醛、乙酰丙酮和碳酸氢铵的摩尔比0.5:1:0.5,催化剂Ⅳ的用量 10(mol)%时,产率最高,可达 93%。催化剂循环使用3次,产率基本不变。该反应具有催化剂经济易得、反应条件温和、环境友好和操作简单等优点。
英文摘要:
      Synthesis of 1,4-Dihydropyridine derivatives catalyzed by (R)-Pyrrolidin-2-yl-methanamine derivatives was developed using aromatic aldehydes, acetacetic ester and ammonium bicarbonate as starting materials. The effects of the reaction temperature, reaction time, solvent, catalyst and nitrogen source on the yield were investigated. The optimal conditions were as followed, the reaction temperature is 70℃, the molar ratio of aromatic aldehydes, acetacetic ester and ammonium bicarbonate is 0.5:1.0:0.5, the amount of catalyst is 10(mol)%. Under theseconditions, the highest yield of 1,4-dihydropyridine reached up to 93%. It was also observed that the catalyst could be recycled three times without obvious loss in catalytic activity. The procedure has the advantages of inexpensive catalyst, mild reaction condition, environmentally benign and simplicity.
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