| 田振芬,吕文华,龚亚斌,张照悦,陈蕴琪,邹爱华.化学通报,2017,80(7):679-683. |
| 蟾毒灵纳米结构脂质载体的制备及性质研究 |
| Preparation and characterization of bufalin nanostructure lipid carriers |
| 投稿时间：2017-01-10 修订日期：2017-02-22 |
| DOI： |
| 中文关键词: 蟾毒灵 纳米结构脂质载体 缓释 毒性 |
| 英文关键词:bufalin (BUF) nanostructure lipid carriers (NLC) sustained release toxicity |
| 基金项目:国家自然科学基金项目（21573070） |
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| 中文摘要: |
| 本文采用高压均质法成功将脂溶性药物蟾毒灵（BUF）负载于纳米结构脂质载体（NLC）中，并对其物理化学性质、体外释放性质及体外肿瘤细胞毒性等进行了研究。结果表明：制备获得的蟾毒灵纳米结构脂质载体（BUF-NLC）粒径小、分散度和稳定性好；具有明显的药物缓释作用；MTT实验表明，将BUF负载于NLC后，作用初期对肿瘤细胞的毒性作用低于原药，作用时间延长，毒性与原药达到一致，说明NLC的包裹并未降低蟾毒灵的药效，而是逐步释放出来，这对克服临床应用中蟾毒灵的高毒副作用有非常重要的意义。 |
| 英文摘要: |
| In this paper, Bufalin loaded nanostructure lipid carriers (BUF-NLC) was successfully prepared by high pressure homogenization. The physicochemical properties, in vitro release and cytotoxicity (MTT) were thoroughly characterized. The results indicated that BUF-NLC exhibited stable system with small particle size and good dispersion. The MTT assay suggested that the cytotoxicity of BUF-NLC on tumor cells was lower than free BUF in the initial stage, but when prolonged the action time, the cytotoxicity of BUF-NLC was consistent with BUF. That showed NLC package did not reduce the cytotoxicity of BUF, but gradually released, which was very important to overcome the side-effects caused by the high toxicity of BUF. |
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