| 张超,徐栋栋,王晶晶,康从民.化学通报,2017,80(8):789-791. |
| 苯并噻唑-2-甲醛合成方法的改进 |
| The Improvement of Synthesis of Benzothiazole-2-carbaldehyde |
| 投稿时间：2017-01-10 修订日期：2017-02-22 |
| DOI： |
| 中文关键词: 2-羟甲基苯并噻唑 氧化反应 二氧化锰 苯并噻唑-2-甲醛 |
| 英文关键词:Benzothiazol-2-ylmethanol, oxidation, manganese dioxide, benzothiazole-2-carbaldehyde |
| 基金项目: |
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| 中文摘要: |
| 以邻氨基苯硫酚为原料，先与羟基乙酸反应合成2-羟甲基苯并噻唑，然后通过氧化反应生成苯并噻唑-2-甲醛。通过对比几种氧化剂的效果，决定采用二氧化锰氧化法，并对氧化反应条件进行了优化。较适宜的反应条件为：2-羟甲基苯并噻唑与二氧化锰的摩尔比为1：8，回流反应8h，产率达到90.2%。该方法适合苯并噻唑-2-甲醛及其衍生物的大规模生产。 |
| 英文摘要: |
| Condensation reaction of 2-aminothiophenol with glycolic acid provided benzothiazol-2-ylmethanol, after the oxidation of it, benzothiazole-2-formaldehyde was obtained. In the present study, by comparing the effects of several oxidants, manganese dioxide was selected as the appropriate agent for the oxidation reaction, and the influence of the feed ratio of the raw materials and the reaction time of reaction on the yield of the product were also studied. The optimum reaction conditions for oxidation reaction were obtained as follows: molar ratio of benzothiazol-2-ylmethanol to manganese dioxide was 1:8, reaction time was 8h, and the yield was up to 90.2%. The synthetic route is suitable for industrial production of the titled compound and its derivatives. |
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