| 唐建生,陈瑶.化学通报,2017,80(11):1009-1013. |
| 钯催化合成香豆素研究进展 |
| Recent Advances in Palladium-Catalyzed Synthesis of Coumarins |
| 投稿时间：2017-02-09 修订日期：2017-06-11 |
| DOI： |
| 中文关键词: 香豆素 钯 合成 羰基化 炔烃芳基化 烯烃芳基化 偶联 |
| 英文关键词:Coumarin, Palladium, Synthesis, Carbonylation, Hydroarylation of alkynes, Hydroarylation of alkene, Cross-coupling |
| 基金项目:湖南省自然科学(2016JJ6021),湖南省高校教改项目(2015-584),湖南第一师范学院科研项目(XYS14N05) |
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| 中文摘要: |
| 香豆素是一类苯并六元含氧杂环类化合物，具有抗氧化、抗菌、抗炎等多种生理活性，受到人们的广泛关注。近年来不断有香豆素的新合成方法报道，特别是高效的过渡金属钯催化合成反应。综述了近20年来钯络合物催化合成香豆素框架的研究进展，主要合成方法包括：羰基化反应，炔烃芳基化反应，烯烃芳基化反应和偶联反应，以期为合成新型香豆素提供参考。 |
| 英文摘要: |
| Coumarins are a common motif in a variety of naturally occurring and synthetic molecules with interesting biological activities, which are verified to have many pharmacological activities such as cytotoxic, antioxidant, antimicrobial, and anti-inflammatory. Recently, lots of new synthetic methods of coumarins, especially the synthetic methods based on highly efficient palladium-catalyzed reactions, have been developed. This review summarizes the early adventures and recent developments in the palladium-catalyzed synthesis of the construction of the coumarin framework in the past twenty years. The main synthetic methods include: carbonylation, hydroarylation of alkynes, hydroarylation of alkene and cross-coupling reaction. The review may provide some references for the synthesis of novel lead compounds. |
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