| 周国永,罗迎春.化学通报,2017,80(10):891-899. |
| 促进纳米载体肿瘤组织渗透性的研究进展 |
| Progress on Polymer Nano Carriers for Improving Deep Tumor Penetration |
| 投稿时间：2017-02-18 修订日期：2017-04-03 |
| DOI： |
| 中文关键词: 肿瘤组织渗透 抗癌药物 纳米载体 肿瘤治疗 |
| 英文关键词:Tumor penetration, anticancer drug, nano-carriers, tumor therapy |
| 基金项目:国家自然科学(21466010) |
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| 摘要点击次数: 3432 |
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| 中文摘要: |
| 过去几十年里，抗肿瘤药物传输取得了巨大的进展，但是肿瘤的高效治疗依然是难啃的“硬骨头”。研究重点逐渐由载体肿瘤聚集向精确靶向、继而向肿瘤组织深处渗透性给药转移，特别是，如何克服种种障碍以实现其均匀地分布于整个肿瘤组织，达到有效的抗肿瘤药物浓度以更好地发挥疗效。本文，从肿瘤组织渗透机理入手，探讨载体的粒径、Zeta电位、形状、结构与化学组成等因素对肿瘤组织渗透性的影响；介绍了多细胞球体、多层细胞培养与体内模型等肿瘤组织渗透性评价方法，并对载体在肿瘤组织渗透性的方面的研究进行了展望。 |
| 英文摘要: |
| Over the last decades, remarkable progress has been made in the field of drug delivery in tumor. But, tumor therapy is a tough nut to crack. However, in spite of significant advances to tumor targeting, an effective treatment strategy for malignant tumors still remains elusive. The research was developed in depth. Most of researches were gradually improved from mainly targeted accumulation to delivery tumor deep tumor penetration for effective effect of tumor therapy. |
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