| 刘清华,杨萍,高传柱,杨波,钱韵旭.化学通报,2017,80(11):995-1001. |
| 铂类抗癌药物-纳米金载药体系的研究进展 |
| Research progresses on gold nanoparticle-based delivery systems of antitumor platinum drugs |
| 投稿时间：2017-04-12 修订日期：2017-06-28 |
| DOI： |
| 中文关键词: 铂类药物 金纳米 载药体系 |
| 英文关键词:platinum drugs, gold nanoparticles, drug loading system |
| 基金项目:国家自然科学基金项目 |
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| 摘要点击次数: 2092 |
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| 中文摘要: |
| 铂类抗癌药物凭借着独特的作用机制，已成为临床治疗中应用广泛的抗癌药物之一。但由于存在较为严重的毒副作用、耐药性等问题，限制了铂类抗癌药物在临床上的使用。为了改善铂类抗癌药物的这些不足，更大限度提高药物的生物利用度并尽量减少其副作用，使用靶向给药体系改变铂类药物体内递送方式受到了广泛的关注。其中铂药-纳米金载药体系因其较大的载药量，易于修饰改造，癌细胞EPR效应，无免疫原性等显著的特点引起研究者们的重视，本文主要介绍近十年来铂类抗癌药物-纳米金载药体系的研究进展。 |
| 英文摘要: |
| Platinum drugs have become one of the most widely used anticancer drugs for their unique mechanisms of action. However, platinum anticancer drugs were limited by serious side effects, drug resistance and other issues. In order to overome the deficiencies of platinum anticancer drugs, improve the bioavailability of platinum anticancer drugs and reduce their side effects, targeted drug delivery system to change the in vivo?transmission?method, the platinum drugs has been widely concerned. Among of them, the platinum drugs-gold nanoparticles delivery system has significantly caused the attention of researchers for its high loading capacity, easy modification, cancer cells EPR effect and non-immunogenicity, etc. In this paper, research progress on nanogold delivery systems for platinum-based antitumor drugs has been introduced in recent ten years. |
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