| 杨小丽,谢宗波,周鹏,艾锋,乐长高.化学通报,2018,81(5):445-449. |
| 电喷雾萃取电离质谱在线监测 Friedl?nder 缩合反应 |
| Online Monitoring of Friedl?nder Reaction Using Extractive Electrospray Ionization Tandem Mass Spectrometry |
| 投稿时间：2017-07-10 修订日期：2017-09-30 |
| DOI： |
| 中文关键词: 电喷雾萃取电离质谱 在线监测 反应机理 Friedl?nder 缩合反应 |
| 英文关键词:Electrospray Ionization Online Monitoring Reaction Mechanism Friedl?nder Condensation Reaction |
| 基金项目:国家自然科学基金 (Nos. 21465002, 21520102007), 江西省优势科技创新团队建设计划项目（No. 20152BCB24003）, 长江学者和创新团队发展计划 (No. IRT13054). |
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| 中文摘要: |
| 质谱在线监测有机化学反应能够实时捕捉反应过程中反应物、中间体、产物的信号及其变化情况,从而推测有机反应机理并加深对反应本质的认识。本研究利用电喷雾萃取电离质谱(EESI-MS)技术在线监测草酸催化的邻氨基苯乙酮与乙酰丙酮间的Friedl?nder 缩合反应；在反应的不同时间点,分别捕捉到了反应物(m/z 136)、中间体(m/z 218、m/z 236)和产物(m/z 200)的准分子离子信号,并记录了它们的信号强度随反应时间的变化趋势,推测出了反应机理。 |
| 英文摘要: |
| Mass Spectrometry online monitoring of organic chemical reaction can capture the signal and change of the reactants, intermediates, and products in the reaction process in real time so as to deepen the understanding of the nature of the reaction. In this study, Extractive Electrospray Ionization Tandem Mass Spectrometry (EESI-MS) were used to monitor Friedlander about 2-Aminoacetophenone and acetylacetone under the condition of using oxalate as a catalyst. At different time of the reaction, the molecular ion peak of reactants (m/z 136), intermediates (m/z 236, m/z 218) and product (m/z 200) signal were captured, the changes of them in the course of the reaction with time trends were recorded. and the reaction mechanism was deduced. |
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