| 姜鹏飞,杨鸿成,季晨阳,陈柱,聂立波.化学通报,2018,81(2):129. |
| 石英晶体微天平传感器及其在生物检测中应用的研究进展 |
| Progress in Quartz Crystal Microbalance and Its Application in Biological Detection |
| 投稿时间：2017-08-20 修订日期：2017-09-17 |
| DOI： |
| 中文关键词: 石英晶体微天平，生物检测，生物传感器 |
| 英文关键词:Quartz crystal microbalance, Biological detection, Biosensor |
| 基金项目:湖南省自然科学基金项目(2016JJ3053)；湖南省大学生研究性学习和创新性实验计划项目(201711535035) |
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| 中文摘要: |
| 石英晶体微天平（quartz crystal microbalance，QCM）是一种具有灵敏度高、免标记、可实时在线检测等优点的重要分析工具。在生物检测领域，QCM与多种信号放大方法相结合，广泛应用于对生物分子的高灵敏度检测。新型耗散型QCM（QCM-D）通过对薄膜厚度、粘弹性等的研究，主要用于考察生物分子的吸附分离、构型变化等微观过程。本文主要阐述了QCM及QCM-D生物传感器的构建及其在DNA、蛋白质、细胞和微生物检测中的研究进展。 |
| 英文摘要: |
| Quartz crystal microbalance (QCM) is a significant analytical tool which has the advantages of high sensitivity, label-free and real-time detection. In the field of biological detection, QCM combining with signal amplification methods is wildly used in ultrasensitive detection of biomolecules. The novel QCM with dissipation (QCM-D) is mainly used to investigate the microscopic processes such as adsorption/desorption and configuration change of biomolecules by studying the thickness and viscoelasticity of the thin film. This paper reviewed the construction of QCM and QCM-D biosensors as well as their research progress in the detection of DNA, protein, cell and microorganism. |
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