| 李毅,汤磊.化学通报,2018,81(2):182-184. |
| 天然产物 Gymnothecaoxazoles A的全合成 |
| The Total Synthesis of Natural Product Gymnothecaoxazoles A |
| 投稿时间：2017-10-11 修订日期：2017-11-20 |
| DOI： |
| 中文关键词: Gymnothecaoxazoles A, 全合成, Robinson-Gabriel环化 |
| 英文关键词:Gymnothecaoxazoles A, Totle synthesis, Robinson-Gabriel cyclization |
| 基金项目:贵州省普通高等学校药物化学工程研究中心（黔教合KY字[2014]219号）、贵州省化学药物开发利用工程实验室、贵州省科技厅基金项目（黔科合ZY字【2013】3016号）、 贵州省科技厅中药现代化项目（黔科合SY字【2014】3017号） |
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| 中文摘要: |
| 以 2,3-二羟基苯甲酸为起始原料，通过酯化、威廉姆斯醚化、水解、酰胺化、Robinson-Gabriel环化、脱保护等一系列反应成功合成了gymnothecaoxazoles A，合成总收率为 20.0%，其结构经1H NMR、13C NMR和HRMS确证,与文献报道一致。此方法原料廉价易得，反应条件温和，操作简单，为快速制备gymnothecaoxazoles A 提供了参考。 |
| 英文摘要: |
| Using 2,3-dihydroxybenzoic acid as the starting material, the natural product gymnothecaoxazoles A was synthesized through esterification, Williams etherification, hydrolysis, amidation, Robinson-Gabriel cyclization and deprotection with 20.0% overall yield. The structure was characterized by 1H NMR, 13C NMR and HRMS. The method has the advantages of easily available and cheap starting materials，mildly reaction conditions and simply conducted procedures，which provides reference for the preparation gymnothecaoxazoles A rapidly． |
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