| 马小燕,胡新军.化学通报,2018,81(5):409-413. |
| 烯酰胺参与的不对称Povarov反应研究进展 |
| Recent Advances in Enantioselective Povarov reaction with enamides |
| 投稿时间：2017-12-15 修订日期：2018-01-05 |
| DOI： |
| 中文关键词: 烯酰胺 双官能化 Povarov反应 不对称催化 四氢喹啉 |
| 英文关键词:enamides, difunctionalization, Povarov reaction, asymmetric catalysis, tetrahydroquinolines |
| 基金项目: |
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| 中文摘要: |
| 烯酰胺因其氮活化的碳碳双键在各类含氮化合物的合成中具有潜在应用价值,其中有机催化的α,β-双官能化反应在有效骨架的构建中得到了广泛使用。烯酰胺参与的Povarov反应作为邻位双官能化反应的扩展应用,为4-胺基-1,2,3,4-四氢喹啉的构建提供一条简洁高效的途径。尽管该类反应如此重要,直到最近才开发出几种高效的不对称催化方案,本文将对这些研究进展做以总结。 |
| 英文摘要: |
| The nitrogen-activated C=C double bonds of enamides have considerable potential for use in the construction of various nitrogen-containing products, and organocatalyzed α,β-difunctionalization of nitrogen-activated double bonds proved to be an efficient and versatile concept, and allowed us to obtain a wide range of useful building blocks. The Povarov reaction with enamides, an extended method for vicinal difunctionalization, provides a straightforward and modular entry to 4-amino-1,2,3,4-tetrahydroquinolines. Despite its importance, it was only very recently that several highly efficient catalytic asymmetric protocols for this reaction have been developed as summarized in this review. |
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