| 於祥,陈娅芳.化学通报,2018,81(8):759-762. |
| 2,3-二苯基-4-噻唑酮类衍生物的合成及抑菌活性研究(英文) |
| Evaluation of 2, 3-Diphenyl-4-thiazolidinone Derivatives as Antifungal Agents |
| 投稿时间：2018-02-26 修订日期：2018-03-23 |
| DOI： |
| 中文关键词: 4-噻唑酮 合成 抑菌活性 |
| 英文关键词:4-thiazolidinone, Synthesis, antifungal activity |
| 基金项目:贵州省教育厅青年人才成长项目（黔教合KY字[2017]169）和贵州省中医药、民族医药科学技术研究专项（QZYY2017-081） |
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| 中文摘要: |
| 本文以取代苯甲醛、苯胺及巯基乙酸为原料,合成了一系列2,3-二苯基-4-噻唑酮类衍生物,其结构经mp、1H NMR和MS确证。抑菌活性试验显示,所有目标化合物表现出中等抑菌活性。其中化合物4的抑菌活性最高能达到62.7%。构效关系研究表明在2,3-二苯基-4-噻唑酮的苯基上引入甲基能增强活性。 |
| 英文摘要: |
| A series of 2, 3-diphenyl-4-thiazolidinone derivatives were synthesized and characterized by mp,1H NMR and MS. Their antifungal activities were also evaluated in vitro at the concentration of 100 μg/mL against seven phytopathogenic fungi, namely Fusarium graminearum, Alternaria alternata, Fusarium oxysporium f. sp. vasinfectum, Pyricularia oryzae, Valsa mali, Alternaria solani and Alternaria brassicae. Amang of all compounds, 4g demonstrated a potential antifungal activity with the highest inhibition rates of 62.7%. Introduction of the methyl group at the phenyl ring of 4-thiazolidinone derivatives could generally increase the potency. |
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