| 莫丽,黄克俊,杨志翔,陈平平,陈治明.化学通报,2018,81(8):727-733. |
| C2轴手性联芳基化合物催化四氢噻喃-4-酮和芳香醛的反应 |
| Reaction of Tetrahydrothiopyran-4-one and Aromatic Aldehyde catalysized By C2 Axially Chiral Biary Compound |
| 投稿时间：2018-03-19 修订日期：2018-03-29 |
| DOI： |
| 中文关键词: C2轴手性联芳基 四氢噻喃-4-酮 芳香醛 |
| 英文关键词:C2 Axially Chiral Biary Tetrahydrothiopyran-4-one Aromatic Aldehyde |
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| 中文摘要: |
| 本文成功合成了4种C2轴手性联芳基有机催化剂,并将其用于催化四氢噻喃-4-酮和芳香醛的反应。研究表明,当二氯甲烷作为溶剂,芳香醛和四氢噻喃-4-酮的摩尔比为r=1.2:5,催化剂Ⅰ的用量为10 mmol%,反应温度0℃,反应时间20 h时,得到较高的产率(85%)及较好的立体选择性(86%)。 |
| 英文摘要: |
| This work was successfully synthesized four kinds of C2axially chiral biary organocatalysts and the reacti-on of tetrahydrothiopyran-4-one and aromatic aldehyde were catalyzed by these catalysts. It demonstrated that when d-ichloromethane as solvent, the molar ratio of aromatic aldehyde and tetrahydrothiopyran-4-one is 1.2 : 5.0, the dosag-e of catalyst is 10 mmol% , the temperature and time of reaction are 0℃and 20 h, we can get good yields (up to 85%) and enantios-electivities (up to 86%). |
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