| 褚翔宇,王小永.化学通报,2018,81(7):625-629. |
| 玉米蛋白/吐温-20复合纳米颗粒对姜黄素的包载作用 |
| Effect of Zein/Tween-20 Composite Nanoparticles on the Properties of Encapsulated Curcumin |
| 投稿时间：2018-04-01 修订日期：2018-04-25 |
| DOI： |
| 中文关键词: 玉米蛋白，吐温-20，姜黄素，包封率，稳定性，荧光光谱 |
| 英文关键词:zein, Tween-20, curcumin, encapsulation efficiency, stability, fluorescence |
| 基金项目:国家自然科学基金项目(21573071) |
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| 中文摘要: |
| 本文采用反溶剂沉淀法制备了玉米蛋白/吐温-20复合纳米颗粒。通过测定玉米蛋白/吐温-20复合纳米颗粒对姜黄素的包封率、稳定性及荧光光谱性质，考察了不同浓度吐温-20对玉米蛋白/吐温-20复合纳米颗粒包载姜黄素的影响规律。相比玉米蛋白纳米颗粒，玉米蛋白/吐温-20复合纳米颗粒能够显著提高姜黄素的包封率、稳定性、荧光发射光谱强度和各向异性。这些结果说明姜黄素通过疏水作用缔合于玉米蛋白/吐温-20复合纳米颗粒的疏水微区。吐温-20作为稳定剂不仅有助于生成较小粒径的玉米蛋白/吐温-20复合纳米颗粒，而且吐温-20与玉米蛋白的结合能够为姜黄素提供更适合的疏水缔合环境。 |
| 英文摘要: |
| In this paper, zein/Tween-20 composite nanoparticles were prepared by anti-solvent precipitation. By measuring the encapsulation efficiency, stability, and fluorescence properties of curcumin in zein/Tween-20 composite nanoparticles, the influence of Tween-20 concentration on the interaction between zein/Tween-20 composite nanoparticles and curcumin was investigated. Compared to zein nanoparticles, zein/Tween-20 composite nanoparticles can significantly increase the encapsulation efficiency, stability, fluorescence emission intensity, and anisotropy of curcumin. These results indicate that curcumin is bound in hydrophobic domains of zein/Tween-20 composite nanoparticles via hydrophobic interactions. Tween-20 as a stabilizer not only helps to produce smaller zein/Tween-20 composite nanoparticles, but also provides a more suitable hydrophobic binding environment for curcumin. |
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