| 姬凌波.化学通报,2018,81(12):1127-1131. |
| 无过渡金属参与下茚并-[1,2-b]吲哚-10(5H)-酮的合成 |
| Tansition-metal-free synthesis of indeno[1,2-b]-indol-10(5H)-one derivatives |
| 投稿时间：2018-05-07 修订日期：2018-08-27 |
| DOI： |
| 中文关键词: 碘化锂 2-吲哚锌 加成-环化 芳基溴 |
| 英文关键词:Lithium iodide, 2-zincioindole, addition-cyclizing, aryl bromides |
| 基金项目:国家自然科学基金项目（21702229） |
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| 摘要点击次数: 1565 |
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| 中文摘要: |
| 发展了一种从3-(2-溴代苯甲酰基)-吲哚出发在无过渡金属参与下合成茚并吲哚酮类化合物的新方法。在甲苯/四氢呋喃（2：1）混合溶剂中，3-(2-溴代苯甲酰基)-吲哚、正丁基锂和碘化锌现场生成的2-吲哚锌，在碘化锂协助下与芳基溴化物发生分子内加成-环化反应，合成了一系列取代的茚并-[1,2-b]吲哚-10(5H)-酮类化合物，且均获得了不错的收率。考察了溶剂、卤化锌、添加剂对产率的影响。 |
| 英文摘要: |
| A convenient method for the preparation of indenoindolones from 3-(2-bromobenzoyl)-indoles without the aid of transition-metal catalysis has been developed. 2-Zincioindole reagents, prepared in-situ from 3-(2-bromobenzoyl)-indoles, n-BuLi and ZnI2, were found to undergo intramolecular addition-cyclizing reactions with aryl bromides in the presence of LiI in a mixed solvent consisting of toluene and THF(2:1). Various substitued indeno[1,2-b]indol-10(5H)-ones can be obtained in good yields. The reaction parameters such as solvent, zinc halide and additive were studied. |
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