| 王建国,李纯斌,姜国玉.化学通报,2018,81(11):972-980. |
| 氨肽酶N荧光探针的研究进展 |
| Progressin fluorescent probes for aminopeptidase N |
| 投稿时间：2018-07-04 修订日期：2018-07-25 |
| DOI： |
| 中文关键词: 氨肽酶N 荧光探针 亲和力型探针 反应型探针 |
| 英文关键词:Aminopeptidase N, Fluorescent probe, Affinity based probes, Reaction based probes |
| 基金项目:国家自然科学基金项目（21502022, 21663005） |
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| 中文摘要: |
| 氨肽酶N(aminopeptidase N, APN)是一种外肽酶,广泛存在于哺乳动物体内,可从蛋白质多肽链的N末端水解中性或碱性氨基酸,在人体中具有多种重要的生理功能。APN可作为癌症诊断的标志物,尿液中APN也可作为肾小球肾炎的早期生物标志物。本文综述了APN荧光探针的研究进展,主要包括亲和力型APN荧光探针和反应型APN荧光探针,并对他们的优缺点进行了比较；最后对APN荧光探针的发展前景进行了展望。 |
| 英文摘要: |
| Aminopeptidase N (APN) is an exopeptidase that widely exists in the body of mammals. It is recognized to have various physiological functions in human body. Herein, the development of fluorescent probes for aminopeptides N was reviewed and generally divided into two categories: affinity based fluorescent probes and reaction based fluorescent probes, with their advantages and shortcomings compared, which may illuminate the future development of APN fluorescent probes. |
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