| 张亦琳,延永,葛颖,王学军,乔成芳.化学通报,2019,82(5):404-414. |
| Ni催化的Suzuki偶联反应 |
| Ni-catalyzed Suzuki Coupling Reaction |
| 投稿时间：2018-10-28 修订日期：2018-11-22 |
| DOI： |
| 中文关键词: Ni催化剂 Suzuki偶联反应 C—C键 机理 |
| 英文关键词:Ni catalyst Suzuki coupling reaction C—C bond Mechanism |
| 基金项目:国家自然科学基金（No. 21703135）和陕西省自然科学基础研究计划（No. 2018JQ2070）资助项目 |
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| 中文摘要: |
| Ni催化的Suzuki偶联反应的研究进展被系统综述,从反应的发展历程和近十年各种类型的Ni催化的Suzuki偶联反应(碳卤键断裂类、碳氧键断裂类、碳碳键断裂类、碳氮键断裂类和碳硫键断裂类)进行系统的总结阐述。通过近十年研究,各类新型催化剂、配体、添加剂不断被开发,使反应活性大为提高,反应条件越来越温和,对目前认为Ni催化的Suzuki偶联反应的机理进行了梳理,发现Ni催化的Suzuki偶联反应催化剂循环方式有两种,即Ni(0)/Ni(II)循环和Ni(I)/Ni(III)循环。因此,本文认为研究和发展价廉的金属镍催化剂是研究Suzuki偶联反应的一个重要方向,未来Ni催化Suzuki偶联反应的研究将会集中在机理探究、新型催化剂和配体设计、多类型碳碳键构建(Csp2—Csp3、Csp3—Csp3)以及广泛底物的不对称Ni催化的Suzuki偶联反应。 |
| 英文摘要: |
| Recent progress in Ni-catalyzed Suzuki coupling reaction have been reviewed in detail, including the development path and all kinds of Ni-catalyzed Suzuki coupling reaction’s research progress in recent decade(C—Halo bond cleavage, C—O bond cleavage, C—C bond cleavage, C—N bond cleavage and C—S bond cleavage). Through nearly ten years of research, various new catalysts, ligands and additives have been developed to greatly improve the reactivity and mild reaction conditions, The mechanism of Ni - catalyzed Suzuki coupling reaction was analyzed and found that Ni catalyzed Suzuki coupling reaction can be divided into Ni(0)/Ni(II) cycle and Ni(I)/Ni(III) cycle. Therefore, it is considered that the research and development of cheap metal nickel catalyst is an important direction to study the Suzuki coupling reaction. In the future, the study of Ni catalytic Suzuki coupling reaction will focus on mechanism investigation, new catalyst and ligand design, multi-type carbon carbon bond construction (Csp2-Csp3, Csp3-Csp3) and asymmetric Ni-catalyzed Suzuki coupling reaction of multi-type substrates. |
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