| 王彦妮,冯爱玲,徐榕.化学通报,2019,82(4):291-298. |
| 纳米金属有机骨架材料及其载药应用 |
| Nano Metal Organic Frameworks and Their Application of Drug Delivery |
| 投稿时间：2018-11-29 修订日期：2018-12-22 |
| DOI： |
| 中文关键词: 纳米金属有机骨架 配合物 比表面积 孔隙率 药物负载 |
| 英文关键词:Nano metal organic frameworks coordination compounds specific surface area porosity drug delivery |
| 基金项目:国家自然科学基金(No. 51801001；No.11747061)；陕西省自然科学基础研究计划(No.2015JM5215)；中国博士后科学基金面上项目(No.2016M601878)；陕西省千人计划青年项目；宝鸡市科技计划项目(No.16RKX1-29),国家自然科学基金项目（基金项目号）,国家科技攻关计划,中国博士后科学基金 |
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| 中文摘要: |
| 金属有机骨架材料(MOFs)是指由含氮、氧等多齿有机配体与金属离子通过自组装形成的配位聚合物。由于金属有机骨架材料的大比表面积和高孔隙率等优点使其在药物负载领域有广泛应用。近年来,纳米金属有机骨架材料(NMOFs)因既具有MOFs的特点,又具有纳米材料独特的理化性能,使其兼具药物负载量高、目标靶向性好、表面易改性和生物相容性优良等特点,已然成为一种优异的纳米级载药系统。介绍了NMOFs的常用制备方法,主要包括溶剂热法、反相微乳液法与超声波法,并对其优缺点进行了讨论；详细阐述了载药NMOFs的特性及其不同类型对于各类药物的负载能力；并展望了今后其主要的研究方向是改善生物相容性、实现更有效的表面功能化、扩展生物NMOFs及其负载药物的种类,使其应用到更多疾病治疗上。 |
| 英文摘要: |
| Metal Organic Frameworks (MOFs) are coordination polymers formed by metal ions and polydentate organic ligands with nitrogen and oxygen by self-assembly process, which have been widely applied in drug delivery systems due to their advantages such as large specific surface area and high porosity. Nano metal organic frameworks (NMOFs) materials have not only the properties of MOFs, but also the unique physical and chemical properties of nanomaterials. Taken into account their characteristics of high drug loading capacity, good targeting ability, versatile functionality and good biodegradability, NMOFs have become excellent nano-scale drug delivery systems. This article mainly featured recentresearch progress towards various preparation methods of NMOFs, including solvothermal method,reverse microemulsion method, ultrasonic method. And the advantages and disadvantages of these methods were discussed respectively. Meanwhile,the characteristics of NMOFs used drug deliverysystems and the load of different types of drugs are described in detail. Finally, the future of their main research direction is prospected, which include improving its biocompatibility, more effective surface functionalization, expanding the variety of biological NMOFs and their payload drugs. Therefore, NMOFs can be used into the treatment of more diseases. |
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