| 马莲凤,马莲凤 李惠静 吴彦超,李惠静,吴彦超.化学通报,2019,82(6):516-521. |
| 碱促进的喹啉酰胺类衍生物的绿色合成研究 |
| Base-Promoted Green Synthesis of Quinolinamide Derivatives |
| 投稿时间：2018-12-07 修订日期：2019-02-27 |
| DOI： |
| 中文关键词: 室温 碱促进 酰胺化 喹啉酰胺 绿色环保 |
| 英文关键词:Room Temperature, Base-Promoted, Amidation, Quinolinamide, Environmental-Friendly |
| 基金项目:国家自然科学基金项目（21672046, 21372054） |
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| 中文摘要: |
| 从经济性和环保性考虑，本文以喹啉甲醛和芳香胺为原料，室温下利用廉价易处理的碱作为促进剂成功合成一系列喹啉酰胺衍生物，对所得产物进行了表征，考察了不同溶剂、碱和底物摩尔比对反应的影响，获得了优化的反应条件，并在文末提出了可能的反应机理。该反应具有条件温和、处理简单、收率较好、绿色环保等特点。 |
| 英文摘要: |
| Based on the consideration of economy and environmental protection, a new method for the synthesis of a series of quinolinamide derivatives from quinolinecarboxaldehyde and aromatic amines has been developed by using an inexpensive and easy-to-handle base as the promoter at room temperature.The synthesized products were all characterized. The effects of solvents, bases and substrates molar ratios on the reaction were examined to obtain the optimal reaction conditions, and a possible reaction mechanism was proposed. The reaction possesses many advantages such as mild conditions, simple treatment, good yields, and environmental friendliness. |
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