| 金东亮,李兆周,古绍彬,尚慧杰.化学通报,2019,82(7):579-584. |
| 分子印迹模拟酶的制备与应用研究 |
| Preparation and Application of Enzyme-mimics Based on Molecular Imprinting |
| 投稿时间：2019-01-27 修订日期：2019-04-04 |
| DOI： |
| 中文关键词: 分子印迹 模拟酶 催化 |
| 英文关键词:molecularly imprinting, mimetic enzyme, catalyst |
| 基金项目:由国家自然科学基金（31701694）、国家自然科学基金（U1504330）、河南省科技攻关（182102310230）、河南科技大学青年学术带头人培养工程（13490004）项目资助。 |
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| 中文摘要: |
| 分子印迹模拟酶是应用分子印迹技术合成对目标分子具有特异性催化活性的聚合物，具有良好的化学和物理稳定性、结构预定性以及实用性。本文主要介绍了分子印迹模拟酶的构建策略：印迹过渡态类似物、印迹底物或底物类似物和其他构建途径；探讨了分子印迹模拟酶的制备方法，总结了分子印迹模拟酶在催化反应方面的应用，涉及有机合成催化、食品安全危害物分解、环境污染物降解和临床医学检验等。 |
| 英文摘要: |
| Molecular imprinting catalyst is a man-made polymer which has the specific catalytic activity for the target molecule by using molecular imprinting technology. It also shows good chemical and physical stability, structural predetermination and practicality. This paper mainly presents the construction strategy of the molecular imprinting mimic enzyme: transition state analogs imprinting, substrate or structural analogs imprinting and other construction approaches. The recent research progress of the preparation method has been discussed. The catalytic reactions with the enzyme mimics were summarized in the fields of catalysis for organic synthesis, decomposition of hazardous substances for food safety, degradation of environmental pollutants and examination in clinical medicine etc. |
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