莫天姿,余浩田,谭宇星,刘梦琴,张复兴,邝代治,蒋伍玖.化学通报,2019,82(11):1001-1007,994.
二对甲基苄基锡芳甲酰腙配合物的合成、晶体结构及生物活性
Syntheses, Crystal Structures and Biological Activity of Arylformylhydrazone Di-p-methylbenzyltin Complexes
投稿时间:2019-04-21  修订日期:2019-08-22
DOI:
中文关键词:  有机锡配合物  酰腙  合成  晶体结构  生物活性
英文关键词:organotin complex  hydrazone  synthesis  crystal structure  biological activity
基金项目:湖南省大学生研究性学习和创新性实验计划项目(No. cx1813);衡阳师范学院大学生创新创业训练计划项目(No. cxcy1944);功能金属有机材料湖南省高校重点实验室开放基金项目(No. GN19K07);衡阳师范学院学科群项目(No. 18XKQ01);衡阳师范学院横向项目(Nos. HXKJ201907, HXKJ201908, HXKJ201911)资助
作者单位E-mail
莫天姿 衡阳师范学院化学与材料科学学院 279725945@qq.com 
余浩田 衡阳师范学院化学与材料科学学院  
谭宇星 衡阳师范学院化学与材料科学学院  
刘梦琴 衡阳师范学院化学与材料科学学院  
张复兴 衡阳师范学院化学与材料科学学院  
邝代治 衡阳师范学院化学与材料科学学院  
蒋伍玖* 衡阳师范学院化学与材料科学学院 278370949@qq.com 
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中文摘要:
      二对甲基苄基二氯化锡分别与2-羰基-3-苯基丙酸对硝基苯甲酰腙或2-羰基-3-苯基丙酸-2-噻吩酰腙反应,合成了2个以Sn2O2四元环为中心对称的二对甲基苄基锡配合物{[R(O)C=N-N=C(CH2Ph)COO](p-Me-C6H4CH2)2Sn(CH3OH)}2 (R= p-NO2-C6H4- or C4H3S-) (C1、C2),通过元素分析、IR、1H NMR、13C NMR、119Sn NMR、HRMS以及X-射线单晶衍射等表征了配合物结构。测试了配合物C1、C2的热稳定性以及配合物对癌细胞H460、HepG2、MCF7的体外抑制活性,结果表明:配合物C1、C2对3种癌细胞都有较好的抑制作用,但是C1略优于C2。通过紫外光谱、荧光光谱、黏度法测试配合物C1与小牛胸腺DNA的相互作用方式,结果均显示配合物C1与小牛胸腺DNA的作用是插入结合,并且作用效果较强;用凝胶电泳法研究了配合物C1切割质粒DNA pBR322的能力,配合物C1能够有效的将超螺旋DNA pBR322切割成缺刻型DNA。
英文摘要:
      Two p-methylbenzyl tin complexes containing Sn2O2 four-membered ring {[R(O)C=N-N=C(CH2Ph)COO](p-Me-C6H4CH2)2Sn(CH3OH)}2 (R= p-NO2-C6H4- or C4H3S-) (C1、C2) has been synthesized via the reaction of the 2-oxo-3-phenylpropionic p-nitrobenzoyl arylformylhydrazone and 2-oxo-3-phenylpropionic-2-thiophene arylformylhydrazone with the di-p-methylbenzyl tin dichloride, respectively. The complexes C1 and C2 have been characterized by IR, 1H NMR, 13C NMR, 119Sn NMR spectra, HRMS, elemental analysis and X-ray diffraction. The thermostability of the complexes C1 and C2 and the in vitro inhibitory activities of C1 and C2 on cancer cells H460, HepG2 and MCF7 were tested. The results showed that C1 and C2 had good inhibitory effects on three kinds of cancer cells, but C1 was slightly better than C2. The interaction between C1 and calf thymus DNA was tested by UV, fluorescence and viscosity methods, it suggested that the interaction of the complex to DNA is intercalation. And the ability of C1 to cleave plasmid DNA pBR322 was investigated by gel electrophoresis, it indicated that C1 can effectively cleave DNA pBR322.
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