| 孟祥玉,王钰童,陈官华,王峥峥,黄瑾,许恒毅.化学通报,2019,82(12):1067-1072. |
| 万古霉素在食源性致病菌检测中应用的研究进展 |
| Application of Vancomycin for Detection of Foodborne Pathogens |
| 投稿时间：2019-05-27 修订日期：2019-09-02 |
| DOI： |
| 中文关键词: 万古霉素 磁性纳米粒子 食源性致病菌 分离 检测 |
| 英文关键词:Vancomycin, Magnetic nanoparticles, Foodborne pathogens, Separation, Detection |
| 基金项目:国家重点研发计划(2018YFC1602500)；南昌大学食品科学与技术国家重点实验室研究(SKLF-ZZB-201720) |
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| 中文摘要: |
| 食源性致病菌污染是引起食品安全的主要因素之一，对人类健康构成了严重威胁。万古霉素作为一种对革兰氏阳性菌具有特异性识别功能的小分子，能够修饰在磁性纳米粒子表面，使粒子获得靶向目标菌的能力，结合其他检测方法，可以实现分离检测革兰氏阳性菌的目的。本文对万古霉素功能化的磁珠在革兰氏阳性菌分离检测的研究进展进行了介绍，分析了万古霉素不同修饰方式和检测方法对其检测效果的影响，并对各种方法的检测结果进行了分析比较，最后，提出了万古霉素在食源性致病菌检测中存在的问题，并对其未来应用进行了展望。 |
| 英文摘要: |
| The contamination of foodborne pathogens is one of the main causes of food safety, which pose a serious threat to human health. Vancomycin is a small molecule with specific recognition function of gram-positive bacteria, which can be modified on magnetic nanoparticles, to obtain the ability of capturing of target bacteria, combined with other detection methods, vancomycin can be used to achieve the purpose of capturing and detecting of gram-positive bacteria. The research progress of vancomycin-functionalized magnetic beads in the isolation and detection of Gram-positive bacteria was reviewed. The effects of different modification ways and detection methods of vancomycin on the detection results were analyzed and compared. Finally, the problems of vancomycin in the detection of foodborne pathogenic bacteria was pointed out, and the future application of vancomycin was prospected. |
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