| 苏长会,刘霞,潘涛,沈宏,黄兆琴.化学通报,2019,82(12):1130-1133. |
| 基于1,1-二溴乙烯一锅法合成1,4-二取代-1,2,3-三氮唑 |
| One-Pot Synthesis of 1,4-Disubstituted 1,2,3-Triazoles from 1,1-Dibromoalkenes |
| 投稿时间：2019-07-16 修订日期：2019-09-24 |
| DOI： |
| 中文关键词: 1,1-二溴乙烯 一锅法合成 1,2,3-三氮唑 杂环化合物 |
| 英文关键词:1,1-Dibromoalkene One-pot synthesis 1,2,3-Triazoles Heterocycles |
| 基金项目:江苏省高校自然科学基金（16KJB150007） |
|
| 摘要点击次数: 1261 |
| 全文下载次数: 0 |
| 中文摘要: |
| 以1,1-二溴乙烯和芳基叠氮化合物为原料,碘化亚铜为催化剂,室温下通过一锅法合成了1,4-二取代-1,2,3-三氮唑衍生物。考察了催化剂用量、反应溶剂、反应温度对产品收率的影响。通过IR,MS,1H NMR及13C NMR等对目标产物结构进行确证,并提出了可能的反应机理。该合成方法具有环境友好、条件温和、操作简单、收率高等特点。 |
| 英文摘要: |
| 1,4-Disubstituted 1,2,3-Triazoles were synthesized by a CuI catalysed one-pot reaction using 1,1-dibromoalkenes and aryl azides as raw materials under room temperature. Effects of the amount of catalyst, solvent and the reaction temperature on the yields of product were studied. The structures of the 1,2,3-Triazoles were characterized by IR analysis, mass spectrometry, 1H NMR and 13C NMR spectroscopy. A mechanism to rationalize the reaction was proposed. This method has the advantages of environment friendly, mild reaction conditions, simple one pot operation and high yields. |
| 查看全文 查看/发表评论 下载PDF阅读器 |
| 关闭 |
|
|
|