| 汪蓝,杨乃娣,陈鼎,方海啸,吴琼,李林.化学通报,2020,83(6):488-496. |
| 线粒体特异性检测与调控 |
| Mitochondrial Specific Detection and Regulation |
| 投稿时间：2020-01-19 修订日期：2020-03-18 |
| DOI： |
| 中文关键词: 线粒体 荧光探针 特异性检测 线粒体调控 |
| 英文关键词:Mitochondria Fluorescent probe Specific detection Mitochondrial regulation |
| 基金项目:国家自然科学基金项目（81672508）和江苏省杰出青年基金项目（BK20170041）资助 |
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| 中文摘要: |
| 线粒体（mitochondria）是一种由双层膜包被的细胞器，存在于大多数细胞中，能够通过位于线粒体内膜上的呼吸链产生能量，被称为细胞的"能量工厂"。此外，线粒体参与到细胞分化、信息传递和细胞凋亡等过程，并调控细胞周期和细胞生长。线粒体的功能障碍与多种人类疾病相关，如帕金森氏病、阿尔兹海默氏病、心血管疾病和某些癌症等。鉴于其在生物体中的重要作用，线粒体一直是科学家们的研究重点。本文就线粒体特异性检测和调控研究的最新进展进行了综述。 |
| 英文摘要: |
| Mitochondria are bilayer-membrane organelles that are found in most cells. They are called as "Energy factories" as they can generate energy through the respiratory chain. Mitochondria are involved in cell differentiation, signaling and apoptosis, and they can also regulate cell growth and cell cycle. Mitochondrial dysfunction is associated with many human diseases such as Parkinson's disease, Alzheimer's disease, cardiovascular disease and cancer. Due to its important role in both cells and organisms, mitochondria have been the focus of research for a long time. This review provides the latest progress of mitochondrial-specific detection and regulation. |
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