| 闫金花,张秀欣,杨宇鑫,钟启迪.化学通报,2020,83(8):735-740. |
| 3-氰基-1,4-二氢吡啶衍生物的合成 |
| Syntheses of 3-Cyano-1,4-dihydropyridine Derivatives |
| 投稿时间：2020-03-22 修订日期：2020-05-11 |
| DOI： |
| 中文关键词: 1,4-二氢吡啶 合成 硼氢化钾 3-氰基吡啶 |
| 英文关键词:1,4-Dihydropyridine Synthesis Potassium borohydride 3-Cyanopyridine |
| 基金项目:河北省教育厅青年基金项目（QN2019165）资助 |
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| 中文摘要: |
| 1，4-二氢吡啶类化合物具有多种生物活性，在临床上受到广泛应用，普遍用于各类心脑血管疾病的治疗。以3-氰基吡啶和含不同取代基的溴化苄为原料在加热回流15h的条件下合成中间体盐；以硼氢化钾（KBH4）作为还原剂，在冰水浴搅拌的情况下，与中间体盐反应，合成了15个结构新颖的1，4-二氢吡啶衍生物（a~o），产率可达85%~90%，其结构经1H NMR、13C NMR和质谱进行表征。该方法具有成本低、环境友好、操作简单、产率高的特点。 |
| 英文摘要: |
| 1,4-dihydropyridine compounds have a variety of biological activities and are widely used in the treatment of various cardiovascular and cerebrovascular diseases. The intermediate salts were synthesized from 3-cyanopyridine and benzyl bromide containing different substituents under the condition of reflux for 15 hours. Potassium borohydride (KBH4) was used for the reduction of the intermediate salts in an ice-water bath, 15 relatively novel 1,4-dihydrogen pyridine derivatives (a~o) were synthesized with the yield of 85%~90%. Their structures were characterized by 1H NMR, 13C NMR and MS. The method has the characteristics of low cost, environmently friendly, easy operation and high yield. |
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