| 吴斯佳,吴坤远,曾绍校,李玉霜,陈俊德.化学通报,2020,83(11):997-1006. |
| 胶原静电纺丝研究进展 |
| Research Progress in Collagen Electrostatic Spinning |
| 投稿时间：2020-05-11 修订日期：2020-07-01 |
| DOI： |
| 中文关键词: 胶原 静电纺丝 制备 研究进展 |
| 英文关键词:Collagen Electrostatic spinning Preparation Research progress |
| 基金项目:国家自然科学基金项目（41676129，41106149）资助 |
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| 摘要点击次数: 1906 |
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| 中文摘要: |
| 胶原是细胞外基质的主要结构蛋白，广泛存在于各类动物机体中。天然胶原存在纤维形态不一、机械性能差等不足，限制了其工业规模化应用。因此，如何有效地制备出性能优良的胶原材料成为热点问题。静电纺丝技术是一种新兴的纳米材料制造技术，利用该技术可获得具有不同结构和性能的胶原基纳米纤维材料，制成的纳米纤维材料展现出密度低、弹性高等优异特性，有望广泛应用于组织工程、医学、载体等领域。本文将从胶原的单独静电纺丝及其影响因素、胶原共混静电纺丝和影响因素以及应用等方面介绍胶原静电纺丝技术的研究进展，并针对存在的问题和发展方向进行了讨论和展望，为胶原的应用提供一定的理论指导和技术支撑。 |
| 英文摘要: |
| Collagen is the main structural protein of the extracellular matrix, and is found throughout the bodies of all kinds of animals. However, natural collagen has unevenness fibers, poor mechanical properties, which limits its industrial applications. Finding a way to produce a thermostable protein that shares the good properties of collagen is an important issue. Electrostatic spinning technology is a new kind of nano-material manufacturing technology. It is used to produce collagen-based nanofiber materials with different structures and properties. The prepared nanofiber material exhibits excellent characteristics such as low density and high elasticity, and is expected to be widely used in tissue engineering, medicine, chemical carrier and other fields. This paper discusses the progress in collagen electrospinning technology with respect to single static spinning of collagen and its influencing factors, collagen synthesis electrostatic spinning and its influencing factors, and applications of collagen electrospinning. The existing problems and directions for development are also discussed so as to provide theoretical guidance and technical support for the use of collagen. |
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