| 王艺颖,董钰漫,尹伟,刘环宇,孟涛.化学通报,2020,83(10):875-882. |
| 全细胞生物催化过程强化的研究进展 |
| Progress in the Process Intensification of Whole-Cell Biocatalysis |
| 投稿时间：2020-05-21 修订日期：2020-06-12 |
| DOI： |
| 中文关键词: 细胞催化 传质 微尺度 过程强化 膜 |
| 英文关键词:Cell catalysis Mass transfer Microscale Process intensification Membranes |
| 基金项目:国家自然科学基金项目（21776230）资助 |
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| 中文摘要: |
| 全细胞催化是利用细胞进行的生物催化过程。由于细胞膜的传质阻碍，细胞催化效率远低于游离酶催化。提高传质从而强化反应过程是全细胞生物催化亟待解决的关键问题。本文从过程强化的角度，讨论了近年来改善全细胞催化传质问题的方法，包括改善细胞膜的透性屏障作用、利用微化工手段强化传质等，并分析了各类方法强化催化过程的机理、优势和不足。探讨了全细胞生物催化过程强化的发展方向，以期为该领域的工程技术发展提供借鉴和参考。 |
| 英文摘要: |
| Cells are the main tool in whole cell biocatalysis. Cell membranes has the disadvantage of resistance to mass transfer, so the efficiency of cell catalysis is much lower than that of free enzyme catalysis. Improving mass transfer to intensify the reaction process is a key issue to be solved in whole cell biocatalysis. Herein, we summarize recent progresses in this field from the perspective of process intensification, which includes improving cell membrane permeability and using microfluidic tools. Moreover, the mechanisms and characteristics of these methods are analyzed. In addition, the challenges and perspectives for further advancing whole cell biocatalysis process intensification are proposed, which provides a reference for the development in this field. |
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